The match will take place at the Harry Gwala Stadium, with the date still be announced.
The Team of Choice booked their spot in the quarterfinals after a penalty shoot-out win over Bidvest Wits at the Harry Gwala Stadium last Friday night, while Highlands Park, losing finalists in the 2019 MTN8, saw off Black Leopards, also on spot kicks.
The two sides met at the start of the season, with the league encounter ending 1-1 in Pietermaritzburg after the Lions of the North had scored in added time.
Kaizer Chiefs v Orlando Pirates
SuperSport United v Golden Arrows
Chippa United v Mamelodi Sundowns
Maritzburg United v Highlands Park